Controlled and Sustained Release Formulations
Controlled and sustained release formulations have become essential in improving the efficacy of long-term therapies and patient adherence. By releasing the active pharmaceutical ingredient (API) in a controlled manner over an extended period, these systems maintain therapeutic drug levels in the bloodstream for longer durations, reducing the need for frequent dosing. This is particularly beneficial for the management of chronic diseases such as hypertension, diabetes, and pain. The use of depot injections, polymeric matrices, and implantable devices has expanded the options for sustained drug delivery. Extended-release formulations are designed to release the drug at a constant rate, while pulsatile release systems can mimic the body’s natural release patterns, providing a more physiological response. Challenges related to formulation stability, release kinetics, and manufacturing are also part of ongoing research in this area.
Keywords: sustained release, controlled release, depot injections, polymeric matrices, implantable devices, drug release kinetics, patient adherence.
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