16^th World Drug Delivery Summit May 30-31, 2022 Milan, Italy

Authors are called to contribute and help in shape of the conference through cessions of their exploration objectifications, papers ande-posters. In addition, the exploration benefactions helps to regulate the abstract, formative, empirical, experimental, or theoretical work in all areas of Pharmaceutical Science are cordially invited for donation at the conference. The conference ask for benefactions of objectifications, papers that address themes and motifs of the conference, including numbers, tables and references of exploration accoutrements.

1. Smart drug delivery

​Smart drug delivery, sometimes called targeted drug delivery, is a method of specifically delivering drugs to a patient in a way that will increase the concentration of the drug in some parts of the body in comparison to others. This process is based on a method that delivers a certain amount of drug for an extended period to a targeted area in the body.

•Passive targeting

•Active targeting

      2. Drug delivery for CNS drugs 

Drug delivery in the Brain to cure CNS disorders is a challenging task. Generally, the drugs for CNS diseases enter through systematic blood circulation. The major barrier which stops the drug to reach the brain is BBB as it protects the brain from various toxins and stops any foreign product to enter but after frequent studies, many other ways have been generated for drug delivery in brain-like alterations of administration routes, non-invasive techniques to increase uptake of brain drug, delivery through BBB, nanoparticles for brain imaging, etc. Gene therapy is an innovative form of drug delivery in the CNS and provides the controlled delivery of drugs.

•Viral vector

•Non-viral nanoparticles

•Exosomes

•Delivery of drug through AT in BBB

     3. Delivery of biologics drug 

Birth medicines are the class of drugs developed through the living organism. Birth medicines are largely potent and have high selectivity of conduct as they are formed through recombinant technologies. Biologics are quick when fitted, their oral operation can take a couple of twinkles to several hours to start working and walls in the gastrointestinal tracts limit the medicine immersion.

 • Intravenous infusions

 • Tone-injections

     4. Magnetic drug delivery 

​Magnetic drug targeting is a method in which the external magnetic fields manipulate the magnetic drug carrier inside the body to reach the targeted destination. In this process, the magnetic particles such as iron oxide nanoparticles are the component of drug vehicle, which provides an ease for magnetic guidance.

• Magnetic drug carrier
• Magnetic nanoparticles

     5. Routes of drug delivery 

Specifics can be taken in a variety of ways — by swallowing, inhalation, immersion through the skin, or intravenous injection. Each system has advantages and disadvantages, and not all styles can be used for every drug. Perfecting current delivery styles or designing new medicine routes can enhance the use of being specifics.

 • Intramuscularly medicine delivery

 • Cutaneous medicine delivery

 • Intravenously medicine delivery

• Inhalation medicine delivery

     6. Vehicles of drug delivery 

A drug vehicle is a carrier or an inert medium used as a solvent in which a medicinally active agent is formulated and or administered. Drug delivery vehicles must discharge the drugs at a specific site on time and with negligible side effects. The vehicle provides the stability to drugs. The goal of this is to increase drug efficacy and to make the process easy to target the specific site.

•Liposomes

•Proteins

•Micelles

•Dendrimers

•Neoplasm

•Biodegradable particles

•Lipids

•Artificial DNA nanostructure

•Magnetic nanomaterial

     7. Drug delivery to BBB 

​The main function of BBB (Blood-Brain Barrier) is to protect the brain from various toxins and drug delivery to the brain; the therapeutically active agents/drugs have to cross the BBB for treating brain-related disorders. Drug delivery through BBB can also help in curing the tumour of the Blood-brain barrier as tumour cells recognize the BBB at a very early stage and destroy it. It has been confirmed that in several disorders the BBB is disrupted and causes various problems to the brain therefore it is important to increase the process and innovate different methods for drug delivery in the brain without any side effects.

•Brain permeability enhancer

•Nanoparticles

•Alteration of administered route

     8. Transdermal drug delivery 

​Transdermal drug delivery is a method of delivery of therapeutically active agents through the skin. In comparison to the oral dosage system, the transdermal drug delivery system can offer a controlled dosage delivered through the skin and can reduce the various side effects. This system of drug delivery contains relatively high amount of Active pharmaceutical ingredients (API). The drug penetrates through the corneum and passes through the dermal layers without any accumulation. They provide a specific dose to the bloodstream via the skin.

•Bio textiles

•Transdermal patch technology

•Inorganic nanoparticles

•Polymers of Transdermal DDS

     9. Smart or targeted drug delivery in cancer therapies 

​In the case of cancer therapies, smart drug delivery has proved successful. Advances in the smart drug delivery system for cancer therapies have reduced the chances of side effects.  The performance of anti-cancer agents used in cancer diagnosis and treatment has improved by enhancing the controlled release of drugs and smart Nano carriers have designed for the targeted delivery of drugs. Dendrimers, the tiny sphere-like structures have engineered carefully to have many loose ends for the attachment of other molecules such as targeting agents that can identify a cancer cell and differentiate it from a healthy cell.

•Protein-based Nano carrier

•Micelles

•Supramolecular

•Hydrogel

     10. Controlled drug delivery 

​The controlled medicine delivery is aimed at releasing the accurate cure or quantum of a medicine directly in the asked zone at the time of demand. Controlled medicine delivery improves the exertion of the remedial agents by adding the medicine stability, solubility and reducing the side goods. Thus, they can move more freely in the mortal body as compared to bigger accoutrements.

 • Mongrel accoutrements

 • Injectable biomedical lathers

 • Nanofibers

     11. Nanoparticles based drug delivery 

​Nano delivery or Nano medicine system is new but developing in which the nanoparticles are used as a tool for drug delivery, which delivers the drugs to the targeted sites. Nano medicine is a developing field that implements the use of techniques of nanoscience in medical biology for disease prevention and treatment.  Nanomaterials are material with sizes ranging between 1 and 100nm, which affects the frontiers of Nano medicine starting from biosensors, drug delivery, microarrays test to tissue engineering. As nanomaterials are designed at the atomic or molecular level, they are usually small-sized.

•Organic Nano carriers

•Inorganic Nano carriers

•Protein-based Nano carriers

     12. Artificial intelligence in drug delivery 

Artificial intelligence in drug delivery has contributed to the 3D structures of protein, which helps in predicting the effect of compound along with the safety. In addition, AI helps in predicting drug-protein interactions and determines drug activity. In the pharmaceutical industry, the use of Artificial intelligence is increasing very rapidly especially in the digitalization of data as it handles a large amount of data with greater automation. AI in the development of pharmaceutical products can be imagined that it can give rational drug design. AI is involved in all the sectors of pharmaceuticals including drug discovery, QA/QC, product marketing, etc.

•Aromatase inhibitors

•Cheminformatics

     13. Self- emulsifying drug delivery system 

​ Self-emulsifying drug delivery system varies from other lipid-based preparations mainly due to the spontaneous formation of stable isotropic oil/water emulsion, of fine lipid droplets on light agitation in an aqueous solution. It is also reported to have properties that help in enhancing the solubility and absorption rates because many bioactive agents have less solubility and absorption limits their pharmacological applications.

• Lipids/oils

• Surfactants

• Co-surfactants

• Active pharmaceutical ingredients

     14. Microencapsulation drug delivery system 

​Microencapsulation is a process in which the solid, liquid, and gas can be enclosed in microscopic particles by using the thin coatings of wall material. Microcapsules and microspheres can be used for control as well as for targeted drug delivery to specific sites in the body. It is used to slow the release of drugs in the body and reduces the toxic side effects of some drugs by preventing the release of a high concentration of drugs into the blood/body. There are different methods of microencapsulation such as solvent evaporation, in situ polymerization, interfacial crosslinking, matrix polymerization, and interfacial poly condensation.

•Kinetics of drug release

•Microcapsule composition

      15. Pulmonary drug delivery system 

Pulmonary medicine delivery system includes inhaler, nebulization, and dry greasepaint inhalation. They give near proximity to blood inflow. In this system, lower boluses can be used to avoid poisonous goods. The use of pulmonary medicine delivery systems using colloidal carrier systems has further physiological factors. The medicines used in the treatment of asthma or gobbled insulin have been developed using newer technology. There has been a constant attempt to deliver opioids by the inhalation route.

 • Bronchial rotation

 • Lung concurrence medium

 • Trans epithelial medicines transport

      16. Niosomes drug delivery system 

Noisome are microscopic vesicles made from non-ionic surfactant and cholesterol following hydration which may be unilamellar or multilamellar. Noisome, are considered novel drug delivery systems, which can improve the solubility and stability of natural pharmaceutical molecules. Noisome are formed to provide targeting and controlled release of natural pharmaceutical compounds. This system has an expectant future in pharmaceutical uses, mostly with the improving availability of advanced schemes to overcome the blood-brain barrier and target the Noisome to the brain.

•Non-ionic surfactants

•Alkyl ethers

•Polyoxyethylene fatty acid ester

•Cholesterol

      17. Implantable drug delivery system 

​Implantable drug delivery system are being developed to release the therapeutically active agents/drugs into the bloodstream continuously as well as free patients from being hospitalized to receive frequent injections. Implantable drug pumps are used to transport insulin for the treatment of diabetics and to administer pain medications directly to the spine. They are typically programmable “active” devices which require regular supply of the medication through an access port.

• Active polymeric implants
• Passive polymeric implants 

      18. Intranasal drug delivery 

Intranasal drugs are taken through the nose. For convenience and reducing pain, there is no decrease in the bioavailability of drugs managed nasally.  Directly delivers to the cerebrospinal fluid due to the nose-brain pathway, which helps to reduce the commencement time.  Intranasal therapeutically active drugs take about 3–5 minutes to get absorbed.

•Opioids administration

•Pharmacokinetics

      19. Intra-articular drug delivery 

​The size of the medicine patch has got to beapprox. 3 – 5 μ. Microspheres that are designed to enhance their uptake by the synovium could also increase the abiding time of drug in intra-articular apkins.

 • Diseased modified approaches

 • Polymeric patches as a platform for medicine release

 • Gene remedy as forestalment 

      20. Buccal mucosal drug delivery 

In buccal medicine delivery, the medicine is placed between the epoxies and the cheeks. The buccal mucosa is veritably lower passable with a large immobile face which results in slower onset and is more suitable for sustained- release medications, whereas sublingual medicine delivery has a more dramatic onset. Also for the ease in administration, it avoids the first-pass effect and systemic elimination. Toxin or uninvited side goods are significantly reduced.

 • Bio adhesive delivery

 • Mucoadhesive polymers

 • Medicine saturation

      21. Ocular drug delivery 

​Optical medicine delivery is a slightly delicate task for medicine delivery due to colourful defensive walls. There are specific and different routes for medicine delivery in the eyes. There are three primary styles of delivery of optical medicines to the eye are topical, original optical, and systemic. The most applicable system of administration depends on the area of the eye to be treated. It shows numerous advantages similar as lower vexation, no pain, sterilization, ease of eye drop expression, and numerous others.

 • New optical medicine delivery

 • Conventional optical medicine delivery

      22. Oral drug delivery 

It is the most common route of medicine delivery. The oral immersion occurs through 4 different pathways-Trans cellular, Para cellular, carrier-intermediated transcellular, and eased transport. This route is preferred most because of its cost-effectiveness, ease of product, and are pathological conditions similar to stomach cancers, infections, inflammations, bowel conditions, gastro-duodenal ulcers, and gastroesophageal influx diseases.

 • Biocompatibility

 • Nano confines

 • Carbon nanotubes

 • Colon targeting

      23. Sub lingual drug delivery

​It involves placing the drug under the tongue or buccal administration, which involves placing the drug between the gums and cheeks. The sublingual administration of the drug means the placement of the drug under the tongue and the drug reaches directly into the bloodstream through the ventral surface of the tongue and the floor of the mouth. The drug solutes are rapidly absorbed into the reticulated vein, which lies under the oral mucosa, and transported through the facial veins, internal jugular vein, and brachiocephalic vein and then drained into the systemic circulation.

•In vitro Evaluation

•In vivo Evaluation

•Sub lingual tablets

•Films

      24. Topical drug delivery system 

A topical drug delivery system is a method of drug delivery applied to a particular part of the body. There are various forms of topical drug delivery systems such as lotions, ointments, gels, powders, etc. mainly creams and ointments. This is a fine alternative to oral drugs for the patient with having the risk of vomit and children. Reduce the chances of side effects and causes no pain. This way is easy to administer and saves the chances of being hospitalized.

•Skin penetration

•Product stability

•Cosmetic acceptability

      25. Thin film drug delivery 

​Thin- film medicine delivery has been proved as an advanced volition to the traditionally used tablets, capsules, and liquids. They can be administered via immersion in the mouth. Also in size, shape, and consistence to a post stamp, thin- film strips are classically designed for oral administration, with the stoner placing the strip over or under the lingo or along the inside of the cheeks (buccal). Similar medicine delivery options allow the drug to shirk the first-pass metabolism thereby making the drug more bioavailable.

 • Plasticizers

 • Stabilizing agents

 • Active medicinal constituents

 • Oral strips in development

The medicine delivery request is prognosticated to reach approx. USD billion by 2023 from USD billion in 2018, at an Emulsion Annual Growth Rate of6.4 during the prognosticated period. The Growth in the request of medicine delivery is substantially directed by the increase in the frequency of habitual conditions, growth in technological advancements and the biologics request, and new product launches. On the other hand, the threat of needle stick injuries (numerous Infections) and the rise in pricing pressure are anticipated to claim request growth in the forthcoming times. In addition, the cases’ heartiness has progressed vastly with ever- perfecting robotization, and possibilities and capabilities of massive improvements in this field have pushed the medicine delivery assiduity to a new height, and in having an astonishing growth in medicine delivery systems for hormones and cardiology agents. The global request for advanced medicine delivery systems is prognosticated to quantum to a value of$196.4 billion by 2025 at a7.2 CAGR

Medicine delivery appertained to the phrasings, technologies, approaches, inventions and systems for transporting a pharmaceutical emulsion in the body as demanded to safely achieve its needed remedial effect. It is important to take a Regard on this content as it is directly related to one’s life. The request is presently estimated to be worth approx. USD18.5 billion for the time 2018 and is anticipated to reach USD51.7 billion by the end of 2025. 

Medicine Delivery 2022 conference provides you a great networking with peer networks. Also, comprise, Keynote Speaker Session, speaker faculty over 2 full days participating substantiation Grounded, Workshops, Interactive sessions, a Admixture of Health care units and Academia Delegates, Networking give a devoted forum for the advancement, prosecution, and exchange of information about medicine delivery. Professionals give a principal technical gathering to detailing and chancing out about the most recent new period advancements created over the span of time alongside examining their operations. Generally, accredited speakers, the most recent ways, methodologies, and the most breakthrough updates in Drug Delivery are suggestions of this meeting.