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Scientific Program
16th World Drug Delivery Summit, will be organized around the theme “Future Prospective and New Era Technologies in Pharmaceutics and Drug Delivery”
Drug Delivery 2022 is comprised of 25 tracks and 0 sessions designed to offer comprehensive sessions that address current issues in Drug Delivery 2022.
Submit your abstract to any of the mentioned tracks. All related abstracts are accepted.
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Drug delivery in Brain to cure CNS disorders is a challenging task. Generally, the drugs for CNS diseases enter through systematic blood circulation. The major barrier which stops the drug to reach the brain is BBB as it protects the brain from various toxins and stops any foreign product to enter but after frequent studies many other ways have been generated for drug delivery in brain like alterations of administration routes, non-invasive techniques to increase uptake of brain drug, delivery through BBB, nanoparticles for brain imaging etc. Gene therapy is an innovative form of drug delivery in CNS and provides the controlled delivery of drug.
- Viral vector
- Non- viral nanoparticles
- Exosomes
- Delivery of drug through AT in BBB
Biologic drugs are the class of medicines developed through the living organism. Biologic drugs are highly potential and have high selectivity of actions as they are formed through recombinant technologies. Biologics are quick when injected, there oral usage can take couple of minutes to several hours to start working and also barriers in the gastrointestinal tracts limit the drug absorption.
- Intravenous infusions
- Self-injections
Magnetic drug targeting is a method in which the external magnetic fields manipulate the magnetic drug carrier inside the body to reach the targeted destination. In this process the magnetic particles such as iron oxide nanoparticles are the component of drug vehicle which provides an ease for magnetic guidance.
- Magnetic drug carrier
- Magnetic nanoparticles
Medications can be taken in a variety of ways—by swallowing, by inhalation, by absorption through the skin, or by intravenous injection. Each method has advantages and disadvantages, and not all methods can be used for every medication. Improving current delivery methods or designing new drug routes can enhance the use of existing medications.
- Intramuscularly drug delivery
- Cutaneously drug delivery
- Intravenously drug delivery
- Inhalation drug delivery
A drug vehicle is a carrier or an inert medium used as a solvent in which a medicinally active agent is formulated and or administered. Drug delivery vehicle must discharge the drugs at specific site on time and with negligible side effects. The vehicle provides the stability to drug. The goal of this is to increase drug efficacy and to make the process easy to target the specific site.
- Liposomes
- Proteins
- Micelles
- Dendrimers
- Neoplasm
- Biodegradable particles
- Lipids
- Artificial DNA nanostructure
- Magnetic nanomaterial
The main function of BBB (Blood-Brain Barrier) is to protect the brain from various toxins and in drug delivery to brain; the therapeutically active agents/drugs have to cross the BBB for the purpose of treating brain related disorders. Drug delivery through BBB can also help in curing the tumour of Blood brain barrier as tumour cells recognise the BBB at very early stage and destroy it. It has been confirmed that in several disorders the BBB get disrupted and cause various problems to brain and therefore it is important to increase the process and innovate different methods for drug delivery in brain without any side effects.
- Brain permeability enhancer
- Nanoparticles
- Alteration of administered route
Transdermal drug delivery is a method of delivery of therapeutically active agents through skin. In comparison to oral dosage system, transdermal drug delivery system can offer a controlled dosage delivered through skin and can reduce the various side effects. This system of drug delivery contain relatively high amount of Active pharmaceutical ingredient (API). The drug penetrates through the corneum and passes through the dermal layers without any accumulation. They provide specific dose to the bloodstream via skin.
- Bio textiles
- Transdermal patch technology
- Inorganic nanoparticles
- Polymers of Transdermal DDS
In case of cancer therapies, smart drug delivery has been proved really successful. Advances in the smart drug delivery system for cancer therapies has reduced the chances of side effects. The performance of anti-cancer agents used in cancer diagnosis and treatment has been improved by enhancing the controlled release of drugs and smart nanocarriers have been designed for the targeted delivery of drug. Dendrimers, the tiny sphere like structures have been engineered carefully to have many loose ends for the attachment of other molecules such as targeting agents that can identify a cancer cell and differentiate it from healthy cell.
- Protein based Nano carrier
- Micelles
- Supramolecules
- Hydrogel
The controlled drug delivery is aimed at releasing the accurate dose or amount of a drug directly in desired zone at the time of requirement. Controlled drug delivery improves the activity of the therapeutic agents by increasing the drug stability, solubility and reduce the side effects. Therefore they can move more freely in the human body as compared to bigger materials.
- Hybrid materials
- Injectable biomedical foams
- Nanofibres
Smart drug delivery, sometimes called targeted drug delivery, is a method of specific delivering drugs to a patient in a way which will increase the concentration of the drug in some parts of the body in comparison to others. This process is based on method that delivers a certain amount of drug for extended period of time to a targeted area in the body.
- Passive targeting
- Active targeting
Nano delivery or nanomedicine system are new but developing in which the nanoparticles are used as a tool for drug delivery which delivers the drugs to the targeted sites. Nanomedicine is a developing field which implements the use of techniques of nanoscience in medical biology for disease prevention and their treatment. Nanomaterials are a material with size ranged between 1 and 100nm, which effects the frontiers of nanomedicine starting from biosensors, drug delivery, microarrays test to tissue engineering. As nanomaterials are designed at the atomic or molecular level, they are usually small sized.
- Organic Nano carriers
- Inorganic Nano carriers
- Protein based Nano carriers
The artificial intelligence in the drug delivery have contributed in the 3D structures of protein which helps in predicting the effect of compound along with the safety. Also AI helps in predicting drug protein interactions and determines drug activity. In pharmaceutical industry the use of Artificial intelligence is increasing very rapidly specially in digitalization of data as it handles large amount of data with greater automation. AI in development of pharmaceutical products can be imagined that it can give rational drug design. AI is involved in all the sector of pharmaceutical including drug discovery, QA/QC, product marketing etc.
- Aromatase inhibitors
- Chemo informatics
Self emulsifying drug delivery system (SEDDS) varies from other lipid-based preparations mainly due to their spontaneous formation of stable isotropic oil/water emulsion, of fine lipid droplets on light agitation in aqueous solution. It is also reported to have the properties that helps in enhancing the solubility and absorption rates because many bioactive agents having less solubility and absorption limits their pharmacological applications.
- Lipids/oils
- Surfactants
- Co-surfactants
- Active pharmaceutical ingredients
Microencapsulation is a process in which the solid, liquid and gas can be enclosed in a microscopic particles by using the thin coatings of wall material. Microcapsules and microspheres can be used for controlled as well as for targeted drug delivery to specific sites in the body. It is used to slow the release of drug in the body and reduces the toxic side effects for some drugs by preventing release of high concentration of drug into the blood/body. There are different methods of microencapsulation such as solvent evaporation, in situ polymerization, interfacial crosslinking, matrix polymerization and interfacial poly condensation.
- Kinetics of drug release
- Microcapsule composition
Pulmonary drug delivery method includes inhaler, nebulization, dry powder inhalation. They provides closer immediacy to blood flow. In this system lower doss can be used to avoid toxic effects. The use of pulmonary drug delivery system using colloidal carrier systems has more physiological components. The drugs used in the treatment of asthma or inhaled insulin has been developed using newer technology. There has been a constant attempt to deliver opioids by inhalation route.
- Bronchial circulation
- Lung clearance mechanism
- Trans epithelial drugs transport
Niosomes are microscopic vesicles made from non-ionic surfactant and cholesterol following hydration which may be unilamellar or multilamellar. Niosomes, are considered as the novel drug delivery systems which can improve the solubility and stability of natural pharmaceutical molecules. Niosomes are formed to provide targeting and controlled release of natural pharmaceutical compounds. This system has an expectant future in pharmaceutical uses, mostly with the improving availability of advanced schemes to overcome blood-brain barrier and targeting the Niosomes to the brain.
- Non- ionic surfactants
- Alkyl ethers
- Polyoxyethylene fatty acid ester
- Cholesterol
Implantable drug delivery system are being developed to release the therapeutically active agents/drugs into the bloodstream continuously as well as free patients from being hospitalized to receive frequent injections. Implantable drug pumps are used to transport insulin for the treatment of diabetics and to administer pain medications directly to the spine. They are typically programmable “active” devices which require regular supply of the medication through an access port.
- Active polymeric implants
- Passive polymeric implants
Intranasal drugs are taken through the nose. For the convenience and reducing pain, there is no decrease in bioavailability of drugs managed nasally. Directly delivers to the cerebrospinal fluid due to nose-brain pathway which help to reduce the commencement time. Intranasal therapeutically active drugs takes about 3–5 minutes to get absorbed.
- Opioids administration
- Pharmacokinetics
The size of the drug molecule has to be approx. 3–5 μ. The residing time of drugs in intra-articular tissues may be increased by microspheres that are designed to improve their uptake by the synovium.
- Diseased modified approaches
- Polymeric particles as platform for drug release
- Gene therapy as prevention
Ocular drug delivery is a slightly difficult task for drug delivery due to various protective barriers. There are specific and different routes for drug delivery in eyes. There are three primary methods of delivery of ocular drugs to the eye are topical, local ocular and systemic. The most appropriate method of administration depends on the area of the eye to be medicated. It shows many advantages as less irritation, no pain, sterilization, ease of eye drop formulation and many others.
- Bio adhesive delivery
- Mucoadhesive polymers
- Drug permeation
It is the most common route of drug delivery. The oral absorption occurs through 4 different pathways- Trans cellular, Para cellular, carrier-mediated trans cellular and facilitated transport. This route is preferred most because it is cost effectiveness, ease of production, is pathological conditions such as stomach cancers, infections, inflammations, bowel diseases, gastro-duodenal ulcers, and gastro-esophageal reflux disorders.
- Novel ocular drug delivery
- Conventional ocular drug delivery
In buccal drug delivery, the drug is placed between the gums and the cheeks. The buccal mucosa is very less permeable with a large immobile surface which results in slower onset and is more suitable for sustained release preparations, whereas sublingual drug delivery has a more dramatic onset. Also for the ease in administration, it avoids the first pass effect and presystemic elimination. Toxicity or undesired side effects are significantly reduced.
- Biocompatibility
- Nano dimensions
- Carbon nanotubes
- Colon targeting
It involves placing the drug under the tongue or buccal administration which involves placing the drug between gums and cheeks. The sublingual administration of the drug basically means the placement of drug under tongue and drug reaches directly into the bloodstream through the ventral surface of the tongue and floor of the mouth.
The drug solutes are rapidly absorbed into the reticulated vein which lies under the oral mucosa, and transported through the facial veins, internal jugular vein, and braciocephalic vein and then drained in to systemic circulation.
- In vitro Evaluation
- In vivo Evaluation
- Sub lingual tablets
- Films
Topical drug delivery system is a method of drug delivery by applying onto the particular part of the body. There are various forms of topical drug delivery system such as lotions, ointments, gels, powders etc. mainly creams and ointments. This is a fine alternate of oral drugs for the patient having risk to vomit and to children. Reduce the chances of side effects and causes no pain. This way is easy to administered and saves the chances of getting hospitalized.
- Skin penetration
- Product stability
- Cosmetic acceptability
Thin-film drug delivery has been proved as an advanced alternative to the traditionally used tablets, capsules and liquids. They can be administered via absorption in mouth. Also in size, shape and thickness to a post stamp, thin-film strips are classically designed for oral administration, with the user placing the strip over or under the tongue or along the inside of the cheeks (buccal). Such drug delivery options allow the medication to evade the first pass metabolism thereby making the medication more bioavailable.
- Plasticizers
- Stabilizing agents
- Active pharmaceutical ingredients
- Oral strips in development